Letter by Filippidis et al regarding article, "Evaluating strategies for the treatment of cerebral cavernous malformations".
نویسندگان
چکیده
Cerebral cavernous malformations are common vascular lesions of the central nervous system that predispose to seizures, focal neurological deficits, and potentially fatal hemorrhagic stroke. Human genetic studies have identified 3 genes associated with the disease, and biochemical studies of these proteins have identified interaction partners and possible signaling pathways. A recurring theme dominating the recent scientific literature is the causal link between mutations in the 3 cerebral cavernous malformation genes and hyperactivation of the small GTP exchange protein, RhoA, and the efficacy of reducing this hyperactivation using inexpensive and well-studied medicines, statins. Familial cerebral cavernous malformation offers a unique opportunity to use a personalized genomic medicine approach to identify a subset of patients prone to intracerebral hemorrhage that may benefit from a pharmacological therapy, where presently only neurosurgical options are available.
منابع مشابه
Intraventricular Cerebrovascular Pathologies of Hydrocephalus and Managements
Cavernous malformations (CM), also called cavernous angiomas and cavernomas, are lowflow vascular malformations that constitute 5-13% of all central nervous system vascular malformations (Moriarity et al., 1999; Raychaudhuri et al., 2005). On the other hand, IVC are rare pathological entities, constituting 2,5-10.8% of cerebral CM (Kivelev et al., 2010). The first report of an IVC was published...
متن کاملEvaluating Strategies for the Treatment of Cerebral Cavernous Malformations
Cerebral cavernous malformations are common vascular lesions of the central nervous system that predispose to seizures, focal neurological deficits, and potentially fatal hemorrhagic stroke. Human genetic studies have identified 3 genes associated with the disease, and biochemical studies of these proteins have identified interaction partners and possible signaling pathways. A recurring theme d...
متن کاملPneumocephalus mimicking cerebral cavernous malformations in MR susceptibility-weighted imaging.
We read with interest the article by de Souza et al 1 about the use of susceptibilityweighted imaging (SWI) for the evaluation of patients with cerebral cavernous malformations (CCMs). In this regard, we would like to report the following case: In November 2008, a 38-year-old woman presented with a history of left tinnitus and hypoacusis. The usual MR imaging sequences showed a left acoustic ne...
متن کاملCerebral cavernous malformations: serial magnetic resonance imaging findings in patients with and without gamma knife surgery.
To classify the cerebral cavernous malformations and to investigate the natural history of cavernous malformations according to the classification, 41 patients with 61 cavernous malformations (40 cavernous malformations from 22 patients treated with gamma knife surgery) were regularly followed up using magnetic resonance (MR) imaging for a mean period of 25.5 months in treated cavernous malform...
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عنوان ژورنال:
- Stroke
دوره 42 5 شماره
صفحات -
تاریخ انتشار 2010